DNA quantization: ImagePath Application for Ploidy Analysis

The ImagePath Systems provides vertically integrated imaging products and reagents for the anatomic pathology laboratory.

Current offerings include ImagePath's remarkable integration of reagents, microscope, camera, high-speed computer and propriety imaging algorithms to permit ploidy analysis (DNA measurements in individual, Feulgen stained, cell nuclei) of a thousand or more nuclei in a few minutes...speeds never before thought possible.

This system also is optimized for full color image capture at resolutions of 1315 x 1024 pixels - which provides detail approaching the lens resolution of the microscope. These full color images can be annotated and saved, as well as exported to other graphics programs.

The ImagePath 300 consists of a vertically integrated system for performing rapid image-based DNA Ploidy Analysis with simple, intuitive, menu driven instructions, standardizing these procedures for improved accuracy and repeatability. Full user interaction with measurement results is provided via linked displays. Mouse actions in any image, graph or table causes corresponding data to be highlighted in the other windows.
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DNA Ploidy analysis sample

Benefits:

  • Capture, store & retrieve microscopic images & Measure image parameters
  • Produce specimen reports incorporating images & Produce standardized specimens
  • Interact with results displayed in any image, graph or table via window action linking
  • Produce results that will be comparable lab-to-lab

Ploidy Algorithm

The Ploidy analysis algorithm consists of background analysis and removal, cell detection and segmentation, overlapping cell separation, stain feature analysis, and absorbency peak classification.